Individuals with NF2 have fewer outside signs of the condition than individual with NF1. This form of the disease affects 1 in 35,000 people and has two separate paths to diagnosis:

  • Bilateral vestibular schwannomas that are visualized on magnetic resonance imaging.
  • Family history of NF2 in a parent, sibling, or child, plus unilateral vestibular schwannomas before age 30, or any two of the following: meningioma, glioma, schwannoma, or juvenile posterior subcapsular lenticular opacities (juvenile cortical cataract).

Patients with NF2 often have hearing loss and cataract formation. These can develop during childhood, but are most common during the teenage years or in the early twenties.

Early management of neurofibromatosis type II

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