Unidentified Bright Objects

It is proposed that UBOsUnidentified Bright Objects” be a diagnostic criterion for NF1 since 43%-93% of NF children will exhibit areas of increased T2-weighted signal intensity on MRI screenings.

Recent Journal Abstracts (Full Text where available) regarding UBOs are listed below:

Use of “unidentified bright objects” on MRI for diagnosis of neurofibromatosis 1 in children

Neurology 2000;54:1646-1651
© 2000 American Academy of Neurology

K. DeBella, BSc, K. Poskitt, MD, J. Szudek, BSc and J. M. Friedman, MD, PhD
From the Department of Medical Genetics (K. DeBella, J. Szudek, and Dr. Friedman), The University of British Columbia; and Department of Radiology (Dr. Poskitt), BC’s Children’s Hospital, Vancouver, British Columbia, Canada.

 

MRI abnormalities in neurofibromatosis type 1 (NF1): a study of men and mice.

Brain Dev 1999 Jun;21(4):268-73

Rosenbaum T, Engelbrecht V, Krolls W, van Dorsten FA, Hoehn-Berlage M, Lenard HG.

Relationship between T2-weighted hyperintensities (unidentified bright objects) and lower IQs in children with neurofibromatosis-1.

Am J Med Genet 1996 Feb 16;67(1):98-102

Denckla MB, Hofman K, Mazzocco MM, Melhem E, Reiss AL, Bryan RN, Harris EL, Lee J, Cox CS, Schuerholz LJ.